If I have the money,I would love to give GM CC a try. Most of the full sized V-8 trucks get about 11-13 mpg in pure city driving(the hemi gets much worse). It the GM crewcab got an honest 16 mpg city, it would be a heck of a truck. A buddy of mine get 23 mpg highway with his 2006 5.3 CC Chevy.
If Chevy cleans them up a bit more, then 25 mpg highway is possible with pure ice.Move to a small diesel-maybe a 3.5 liter straight six,and you might approach 30 mpg highway at 60-65 miles per hour with a full sized pickup.It would be a good long trip vehicle,and a good evacuation,Home Depot/ house repairs type vehicle.
A true 4 door pickup is pretty versatile vehicle.
XCEL-Yep, the MDX is a really nice trip vehicle. We spent 16 hours going 250 miles in our Pilot last August; it was not too bad.
You can put an air mattress in the back,fold all the seats,fill in the space between the ft seats and the headrests of the backseats with plywood and foam, and you have about 78" of sleeping length-with enough width for two adults and two leggy greyhounds.
Thanks,
Charlie