My 200 mile trip is about 165 miles of two lane that goes through a small town every 15 miles or so, then the last 35 miles is divided 4 lane with a 70 miles per hour speed limit. I've noticed that if I try to set the cruise at about 72 or more, the mileage starts to drop. It seems the best economy range for me has been in the 60-65 miles per hour area. I'm still at 990 miles, so hopefully it will keep getting better.
Very impressive on the 41.2 mpg 2100 mile trip! Makes you happy you chose a hybrid I'm sure

2006 Toyota Avalon XLS, Blizard White Pearl, Sirius Radio. Car #75
1994 Chevy S10, Sirius Radio. Car #74