97 Mercury Sable, 220,000 miles. Avg 22 mpg
to
07 TCH now at 26,000 miles. Avg 37.5 mpg

No regrets.
I was seriously looking at the Prius a couple of years earlier but I absolutely despised feel of the seats. (Me: Can you replace the driver seat with the one from the Camry? Salesperson: Er, no. Me: Sorry, I don't think I could take 24,000 miles a year on those seats.)