The 2.5S/SL Altimas with a CVT get 31mpg highway, so a little detuning to 158hp (opposed to 175), a bit of hybrid battery help, and an eCVT could definitely make up 2mpg on the highway. The Altima uses the exact same 2.5 that the non-hybrids do, but it's detuned for gas mileage. It's not an Atkinson cycle like the Prius or Camry.

Dark Slate Altima Hybrid
Technology Package
33mpg!