I'm waiting for the long time posters on this site to chip in on what this guy from Indiana is doing. If you have the necessary background, it appears doable.

From this site one realizes the Prius hybrid battery State of Charge runs from 40 to 80% while the Escape is 40-60%. The Escape's hybrid battery pack has heating and cooling devices while it appears the Prius does not. The hybrid battery control module (BCM) is the key component in allowing hybrid battery assist at almost all speeds.

2005 AWD Escape Hybrid
Best tank trip MPG 39.02 (scangauge II) for 402 miles on I-70, 10.3 gallons used over mostly flat terrain.

Best tank trip MPG 34.6 for E30 for 271 miles along I-80 in Indiana and Ohio.