I would have seriously considered an Altima Hybrid (I'm currently driving the Altima Coupe), but they are not available in Alabama yet. I am getting a Prius, to be delivered next week and I am very happy with my decision. But I don't have kids to transport so I did not have to worry about that. My vehicle is mostly for commuting to work and back.

A definite plus on the Altima side is that you can still get the federal tax credit, that credit has expired for the Prius (and the Camry Hybrid).