The following observations apply to my driving with no extraordinary technique save limiting my highway speed to 65 mph max.
Seeing that I own both a 2007 TCH and XLE-V6 I will offer the following...
Without special driving techniques the TCH beats the XLE-V6 in city driving by a margin of 2:1. However on the highway I limit my max speed to 65 mph and the XLE-V6 gets close to 35 mpg on flatland and maybe 30 mpg in modest hills compared to the TCH getting about the same at 65 mph. With the larger trunk of the XLE it has become my road machine of choice. It's added power/passing ability is an added benefit as well.
If the only driving you do is highway I would suggest you at least consider going with the non-hybrid for the same $$ and enjoy it's better highway driving abilities. BUT if you do any amount of city driving it's hard to match the TCH. The V6 sucks gas when sitting at stop and go lights and if you turn the engine off at every light (as the TCH does) I think you'd probably be replacing the starter rather quickly.