I have no doubt that if my commute were reduced to 10 minutes that my lifetime mpg would plummet. The emissions equipment is warming up, the engine is warming up, etc.
But I'm confident it'd still be at 40+ mpg. So Anderbr, to me, depending on what car you're coming from would determine if that's reasonable enough for you to make the switch. If you're coming from a Civic or other non-hybrid gas-miser, maybe not. If you're coming from a gas-guzzler, then maybe it will.
Rick