Ive personally driven both but own a HCH2. I rented a Prius on my trip to Los Angeles from the Bay Area(400mi).

Prius had a lot of leg room for big guys like my pops and I. Another cool feature about the Prius is the touch screen which shows the status of the electric motor and the regenerative braking, radio etc. What impressed me most on this trip is that i was able to take over countless suv's on the highway while getting many wierd looks as if the lil ol hybrid couldnt pack a punch when demanded to. As for interior and style, not really my taste compared the HCH2.
Acceleration wise the Prius has more punch, but im not sure about highway speeds with my HCH as ive only had it for a week and im still breaking it in.