Well let's take the Burgman AN400 as an example. This is quite a good 4 stroke , 4 valve single with fuel injection. Ridden hard I get about 130 miles to a 11.5l tank. That's about 50mpg Imperial.
But this is mixed usage freeway into London followed by hacking through the traffic. Approx 15 miles to the outskirts and then 15 miles in the city. I figure all the inner London riding could be done with electric only. So if I could recharge nightly off mains electricity to help out the petrol driven alternator, I should be able to roughly double the MPG. I should emphasise this is hard riding. Americans with less twitchy throttle hands regularly get 160-170 miles from a tank.
These sorts of bikes get used a lot for commuting and short journeys in Europe which is exactly the travel mix that works well for hybrids. But they are also big enough and fast enough (90-110mph top speed, 400cc-650cc) to handle freeway and even transcontinental touring. The CVT is not as efficient as it could be but it's also wonderfully relaxing and still gives a good turn of speed and acceleration.
As for aerodynamics, the stock fairing/screen is about as aerodynamic as a brick. It's not that bad, but it could be a whole lot better. If you want to see a Motorcycle with the same basic layout as a megascoot but much better aeros, take a look at
http://www.bikeweb.com/image/tid/40 I do understand that this is not to everyone's taste!