Don't forget also that elevation isn't the be all end all of a hills effect on MPG.... Trying this with ascii art.... say you have this hill:
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MAN since they kill spaces on this darn forum it sure is hard to do any ASCII art Sheesh
Going left to right you are probably going to burn more fuel than right to left, but its complicated. Physics says the same amount of "work" is involved in raising the car up then down again (actually the net "work" vertically is zero if I remember my physics right but that's another matter), however, the car is going to have to be in a lot lower "gear" (high RPM for higher torque) to climb the steep hillside than to climb the shallow one going the other way and high RPM's aren't good for gas mileage.... On the other hand you are going to coast a long way down the other side, getting some of that back... now if you go left to right you are probably going to have the brakes on (unless you have a lot of guts) and use loose energy that way. I THINK left to right will be worse for MPG-- but there is a lot involved. Even when regenerative braking hybrids have losses in braking, the energy is stored in the battery, but there is still some lost to heat---its a lot better than loosing all of it.
In any case MPG differences in round trips for each direction aren't that surprising.... there are a lot more reasons behind it than there seems on the surface. Just because you start and end at the same elevation doesn't tell you everything.