None. All have better than average reliability.
Search on Cars.com to obtain an answer that depends upon a number of items including supply and demand. Make sure you compare your region with other regions including the state of California.
GaryG. drives a 2005 Escape Hybrid--the first model year--and has a lifetime mpg average of 45!

The famous "what is your mpg average" question depends upon a number of factors-environmental/traffic/driver skills.
This site has a data base for mileage-take a peek and look at the Escape FAQ section.
This question depends upon one's viewpoint.

Some reviewers/posters state Mercury is "better quality". Keep in mind the hybrid/drivetrain components are identical to the Escape. It is difficult to find an used Mercury Mariner Hybrid due to only several thousand made each year.
2005 AWD Escape Hybrid
Best Interstate
tank trip MPG 39.02 (scangauge II) for 402 miles on I-70, 10.3 gallons used over mostly flat terrain. Aug. 2007
Best
Interstate tank trip E30 MPG 34.6 for 271 miles along I-80 in Indiana and Ohio. May 2008
Best multiple road tank trip E30 MPG 36.2 for 202 miles in Southwestern Pa. July 2008.