DC HiHy,
I find that the A/C can have a significant impact on my FE, especially when I'm trying to keep it up at ~26 mpg.
What I try to do is set it at 75F and auto, then once things have cooled down, manually set it to the lowest fan setting... Even then, it still has an impact on FE but not as much...
However, what "I try to do" and what "I actually do" can end up being quite different depending on which "guest" happens to be sitting in my HiHy. So, gotta live with reality...
-Han-
