I've not seen this situation, but I'd bet it is simply a rounding issue.
Your ending situation (350 miles into the tank) should have driven the MPG up to 52.4. so.. chances are that your 50.5 may have been closer to 50.4. And maybe your 52.2 was close to 52.1 as well.
That's the danger of using small sample-size (in this case, miles or 1/2 gallons used).
Just my 1.51 cents worth.
