The Rochester Institute of Technology just released an E20 (20% ethanol blend) study (link to news brief: http://www.rit.edu/news/?r=47447). Results: average decrease of 23% for carbon monoxide and 13% for hydrocarbons over 100,000 miles. No vehicle component damage from E20 useage. All vehicles were non-flex fuel or in other words normal gasoline engines.
2005 4WD Escape Hybrid
Best Interstatetank trip E20 MPG 34.6 for 271 miles along I-80 in Indiana and Ohio. May 2008
Best multiple road tank trip E20 MPG 36.2 for 202 miles in Southwestern Pa. July 2008.
Best multiple road tank trip E50 38.1 MG for 246 miles in Northern Wisconsin Aug 2012