Your statement is pretty vague. But no, I didn't have that problem. Change the color, and the color changes. Change the voice/volume, and the voice/volume changes. Change what icons are shown on the maps, and the shown icons change. Change if "bread crumbs" are left, and bread crumbs are changed. Are these the values you're referring to?
I don't believe anyone on this forum has had that problem in the past. I know there's a way to reset your system, but I don't remember how. Perhaps it's locked up for some strange reason and just needs to be reset? I'll try to flip through the service manual and see if I can find something that can help.
I looked through the service manual, under the Navi section and troubleshooting. It doesn't list your problem on changing the settings on the screen but it not actually changing anything. It does have a section about the display unit buttons or touch screen buttons not working at all.
For those with the service manual at home, follow along on page 23-130.