NOx and volatile organic compounds (VOCs) are involved in complex photochemical reactions to form ground-level ozone. Recent U.S. Department of Energy-supported studies have strongly suggested that the strict control of NOx emissions may have the unintended consequence of making ambient ground-level ozone worse. The California Air Resources Board (CARB) has put increasingly strict emission limits on NOx emissions in an attempt to reduce ground-level ozone (ozone is an inhalation health concern), for which Southern California is notorious. However, many previous studies have shown that ozone levels are actually higher on weekends (WE) than on weekday (WD) (WD/WE effect) when diesel truck traffic decreases relatively much more than automobile traffic (which mostly are powered by gasoline engines). The DOE studies have confirmed that NOx is reduced significantly more than VOC (HC) and as a result ozone levels increase. It has been discovered that most large urban areas in the U.S. have similar conditions in which ambient ozone levels rise with decreasing ambient NOx levels and that NOx controls in Southern California (and other urban U.S. locations) are generally counterproductive for reducing ambient ozone, they actually increase ambient ozone levels. Were it not for large concurrent HC emission reductions on weekends, weekend ozone would be even higher than it is, and the weekend/weekday ozone difference would be even larger. DOE concludes that gasoline exhaust and gasoline vapor account for ~80 percent of ambient NMHC (VOCs) in on-road samples and at regional air monitoring locations suggesting that gasoline emissions are responsible for the majority of ozone found in the SoCAB. Whether these recent findings change CARB's (or even EPA's) ozone control strategy remain to be seen.